best isekai anime

14 Best New Isekai Anime of 2022

2021 has been a wild year for isekai anime, with tons of new series having aired, but that’s nothing compared to what’s coming up in 2022. With the direction isekai anime has taken in recent years, it’s become apparent that 2022 will be full of even more cool shows, with some truly amazing ones on the horizon.

The best part is that many of them have already begun and it looks like there won’t be any shortage of isekai entries this year. Today we’re going to be taking a look at the top 14 new isekai anime of 2022.

Here are the 14 best new isekai anime of 2022

The anime world is vast and exciting, constantly evolving and growing with new series, genres, and formats. One such evolution has been the isekai genre, a subgenre of fantasy anime and manga where the protagonist is transported to a parallel universe and finds themselves in a fantasy world full of magic, monsters, and epic adventures.

The popularity of the isekai genre has exploded in recent years, with some of the biggest anime of today being isekai. The genre has continued to grow in popularity, with new series being released almost every year, in all kinds of genres and formats. If you are looking for new and fresh, here are the 14 best new isekai anime of 2022.

14. Skeleton Knight in Another World

Skeleton Knight in Another World new isekai anime of 2022

The gamers who keep getting teleported into another world theme need to stop. I can’t live anymore with this false hope. Our MC, a full-time gamer, played video games until he fell asleep and woke up to a new reality. By the time he woke up, he had found himself in the game world.

With no flesh but pure bones, he was equipped with powerful weapons and armor, but his skeleton king struck a frightening appearance not only to enemies but also to himself. On his journey, he saves a beautiful warrior and sets on a way of leading a peaceful life.


Dubbed – Yes

Season – 1(12 Ep.)

13. The Devil is a Part-Timer Season 2

The Devil is a Part-Timer Season 2

The hard-working McDonald’s employee is back after eight years of break. A classical reverse isekai series revolves around a demon lord Satan, who got defeated in the last battle and escaped into the human world. In a world full of humans, he tries his best to hide his identity behind the mask of a regular fast-food employee.

He has stuck in modern-day Tokyo, eager to take his revenge. However, he is powerless in this world and cannot use his magic. Later he comes across the beautiful hero Emi Yusa who dethroned him in the previous world.

Now all of them will eventually get used to living the daily life of a normal human. After almost a decade later, I am excited for the sequel to be released, and I am sure you all are too.


Dubbed – Yes

Season – 2(25 Ep.)

12. The Greatest Demon Lord Is Reborn as a Typical Nobody

The Greatest Demon Lord Is Reborn as a Typical Nobody

The concept of demon lord reborn is getting quite popular and here is another new edition of it. Our MC is a demon lord named Varvatos, the most powerful person alive. He finds his life boring for the role of a demon lord people feared around him.

All his friends and family left him alone, so he decided to be reborn to get some company as a normal human being. However, things got a little tricky. Even though our MC was reborn into a typical village family, both his parents have great magical abilities.

This made mc magical ability still much more powerful for an average person. If you love the shows like Misfit of The Demon King or Wise Man Grandchild, then this one will definitely fit your criteria.


Dubbed – Yes

Season – 1(12 Ep.)

11. Kenja no Deshi wo Nanoru Kenja

Kenja no Deshi wo Nanoru Kenja

The proverb when you love yourself more than anything has an adaptation. Our MC Sakimori is a renowned player of VR MMO Ark Earth online known by the online Avatar of Dunbalf. For the record, he is quite popular in the online community.

One day before going to sleep, he creates a female character based on his avatar just for fun, and on the other day, he wakes into the Ark Earth world. As a female avatar he created last night, he named his new character Mira and introduced her as a disciple of Dunbalf. It’s a refreshing new take that I would like to see how people will react to.


Dubbed – Yes

Season – 1(12 Ep.)

10. The Eminence in Shadow

The Eminence in Shadow

Our isekai protagonist loves to be in the shadows. He always admired those who hide their identity and controlled everything from the shadows. He trains himself every night secretly to prepare for his eventual rise to power. Sadly, our MC’s life ended after a traffic accident, making him fail to achieve his goal.

However, this marked a new journey into a new world. Our MC wakes up in another world and suddenly finds himself as the head of a secret organization called Shadow Garden, which aims to take down an evil cult in the shadows.

Finally, he gets a chance to act out all like he wanted in the previous world. I already read some of the source material and by the time this had been on my radar.



Season – TBA

09. The Rising of the Shield Hero S2

The Rising of the Shield Hero S2

Our hero Naofumi is back. The otaku is suddenly summoned to another world when he finds a book in the library. In this new world, he gets betrayed, loses all money, dignity, and respect. The only hope he had was Raphtalia, the sword of his shield. Later our MC proves his worth and we all get to see a satisfying revenge story. In this season, we continue to see the journey of our MC from zero to hero.

This series has broken many waves on the internet and I don’t think anyone has not heard of this before. However, the series was set to be released for October 2021 but got delayed to April 2022, so if you still haven’t caught up with the first one yet, then now have plenty of time for it.


Dubbed – Yes

Season – 2(38 Ep.)

08. Trapped in a Dating Sim: The World of Otome Games is Tough for Mobs

Trapped In A Dating Sim new romance anime of 2022

This is what happens when the ladies start ruling the isekai world. In this dating game, the girls are the ones ruling the world. They sit around a round table and only beautiful and handsome men get to sit at the round table. Now how can our average MC win the hearts of these ladies?

Well, it turns out our MC has already played the game, so once he gets trapped in it, he already knows all the tips and tricks he needs to rise up in the ranks and sit among the ladies.

The twist of this show is that the main girl of the game is replaced by a shorter version of her who acts like a cocky brat and the main character is overpowered as usual and knows how to kick the asses of the rest of the cast with his overpowered mecha. Yes, there are giant robots in this show as well. This is one of the more enjoyable anime shows I watched this season.


Dubbed – Yes

Season – 1(12 Ep.)

07. Fantasy Bishoujo Juniku Ojisan to

Fantasy Bishoujo Juniku Ojisan to

When a hentai artist decides to write something on gender blender, the final result is something like this. A 32-year-old man is summoned into another world with his handsome friend with a little twist that our MC turns into a teenage girl. Yes, an old man turns into a girl whose love interest is none other than his best friend.

When you leave your whole life alone with a best friend, some forbidden things are doomed to happen. Now to avoid the upcoming calamity, our MC or female lead, whatever we call it, needs to defeat a demon lord so he can turn himself into his original self. The story has many comedic sketches and the release date is not too far away.


Dubbed – Yes

Season – 1(12 Ep.)

06. My Isekai Life

My Isekai Life

Don’t worry about the title; let me make it easy for you. Based on another victim of overworked Japanese employee culture, our MC Yuuji Sano has a harsh working life. Coming from work suddenly finds himself in another world. As a monster tamer in a fantasy-like game world, including the status bars and skills.

Our MC is kind by nature and willing to help anyone in need. However, he has no emotions left due to his previous work life. In this new world, he started taming slimes, became a sage, and set on the adventure. With his new awakened magical powers, we don’t have much info as of now, but judging by the theme of his slime, we all know what slimes are capable of.


Dubbed – No

Season – 1(12 Ep.)

05. Arifureta S2

Arifureta S2

Don’t worry. We are not having a PlayStation two graphics this time. The sequel to Arifureta or copy of the legendary entry The Rising of The Shield Hero. The story follows Hajime Nagumo, who is suddenly summoned to another world as heroes along with his classmates, while his classmates are blessed with powerful stats and abilities he is not.

On an adventure, our MC was betrayed by his classmate and was doomed to die. However, he did not lose hope and survived the bottom of an abyss. In a typical harem style but the fight for survival has just begun.

On his journey back home, there will be a lot of thrilling challenges coming towards our MC. Hajime Nagumo will continue its journey back home in the second season, adding more players to the story.


Dubbed – Yes

Season – 2(25 Ep.)

04. World of Leadale

World of Leadale

Another video game based isekai anime we are going to witness. World of Leadale follows a female protagonist Keina Kagami who finds a new life. In a VR MMORPG game after a horrible incident. She is put on a life support system to survive. One day her life support shut down and she passed away.

Keina wakes up in the body of the avatar she used to play in the game. Her avatar Cayna is quite familiar with her surroundings. Yet she senses that something isn’t quite right and this may not be the same Leadale that she knows. However, this Leadale is 200 years in the future.

As now a high elf, she is starting a new adventure in the future world. The announcement was made at the Virtual Crunchyroll Expo 2021. By that time, I have been waiting patiently for the actual release.


Dubbed – Yes

Season – 1(12 Ep.)

03. Parallel World Pharmacy

Parallel World Pharmacy isekai anime 2022

Brought to us by studio Diomedéa, Parallel World Pharmacy tells the story of Kanji Yakutani, who lost his little sister to a horrible disease at a very young age.

Using the love for his sister as his driving force, Kanji dedicates the rest of his life to learning new medicine and curing the disease, but calamity strikes once again when at the age of 31, Kanji passes away due to overwork only to wake up in another world inside the body of a 10-year-old.

Now heir to the noble De Médicis family Kanji or now known as Falma discovers that this new world is blessed with magic, granted through a guardian deity’s blessing. Host to the guardian deity of medicine, Falma finds out the terrible state of medicine in this world.

Using his knowledge of modern medicine and combining it with his mystic art, Falma once again begins his work to cure every possible disease. With the blessing of creation and reduction and eyes able to diagnose illnesses instantly, he pursues his vision of improving health care in this world, making it accessible to all.


Dubbed – Yes

Season – 1(12 Ep.)

02. Uncle From Another World

Uncle From Another World isekai anime 2022

An Isekai anime starring an uncle is definitely a new one on the list of animes with completely weird names but engaging plots. After nearly 17 years of being in a coma, Takafumi’s uncle Yousuke finally wakes up in the year 2017.

After waking up, he doesn’t seem to recognize the changed world he’s in. The high-speed internet, mobile phones, modern anime waifus, and all such important factors. It turns out that while he was in a coma, Yousuke had been transported into a fantasy world where he became a respected hero. From the small fragment of magic that he still retained, Yousuke shows his adventures to Takafumi through a magic spell.

Surprise Takafumi can’t believe his eyes when he sees that his below-average-looking uncle was quite the popular and heroic type in the fantasy world.

Nonetheless, this anime revolves around Takafumi teaching his uncle the new ways of life while he reminisces about his 17 years of magical adventures and numerous tsundere that were head over heels for him.


Dubbed – No

Season – 1(13 Ep.)

01. Overlord S4

overlord s4 Most Anticipated Anime of Summer 2022

Not surprising that the most awaited sequel to the dark lord isekai fantasy is our top pick. It took an unhealthy amount of time but the fourth season of Overlord finally seems within reach.

The story of this particular dark lord is not something that shies away from tapping into the real demonic potential of the show. Unlike others who try to portray the evil lord as the good guy, Overlord boldly portrays the fact that a being such as Ainz has no space in his heart for mercy.

The only thing he respects is loyalty and bravery. As the lich ruler of the sorcerer kingdom, Ainz Ooal Gown now wants a new challenge that will make it worth his time.

With the mightiest warriors in the whole world preparing to face off against the Overlord, the clock ticks for the ruler before he enters the battle which could possibly be his last. With his rivals who plan to ally with the slain theocracy as being their only means of victory against the impregnable conqueror, it’s now up to the Ainz and his generals to once again grace us with their overwhelming force and defend his rule.


Dubbed – Yes

Season – 4(52 Ep.)

Also, Check Out

10 Best Upcoming Fantasy/Isekai Anime of 2022

10 Best Isekai romance anime to watch

10 Best Classic OG Isekai Anime

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Do you agree with our list of the 14 best new isekai anime of 2022? Tell us your favorite isekai anime in the comment below.

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Welcome to MojoTop10, where you'll find the best anime, games, and movies in our top 10 rankings! I'm Samir, an anime industry expert with over 10+ years of experience. I'm also a big fan of games and movies.

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